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The technology driving our device

Our insulin resistance measurement device uses ultra-sensitive point-of-care biosensor technology to simultaneously measure blood glucose and insulin levels. Low cost biological and chemical reactions by detecting signals proportional to the concentration of analyte (glucose or insulin) in the blood.  It is small and has many advantages compared to laboratory-based insulin resistance tests, including ease of use, rapid results and low cost.  This same biosensor technology can be applied to other biomarkers, providing highly sensitive and accurate point-of-care measurement for a variety of diseases.
What are the main components of our device?
A typical biosensor consists of the following components:
Biomarker: A biomolecule of interest (analyte) that is being identified and measured. For instance, glucose is an analyte in a glucose biosensor.
Bioreceptor: A biomolecule that recognizes the analyte specifically. Enzymes, cells, small molecules and antibodies can be used as a bioreceptor in a biosensor. The process of signal generation (in the form of light, heat, pH, charge or mass change, etc.) upon interaction of the bioreceptor with the analyte is termed biorecognition.
Transducer: A component of the biosensor that converts one form of energy into a measurable signal. For example, transducers can generate either optical or electrical signals that are proportional to the amount of analyte bound to bioreceptors.
Electronics: This is the part of a biosensor that processes the transduced signal and prepares it for display. It consists of complex electronic circuitry that performs signal conditioning, such as amplification and conversion of signals from analog to digital form.
Display: This consists of a combination of hardware and software that depicts biosensor results in a user-friendly manner. The output signal on the display can be numeric, graphic, tabular or an image, depending on the requirements of the end user.

What is the working principle of our device?

A small blood sample is applied to our specialized test strip to quantify blood glucose and insulin and calculate insulin resistance. Our particular biosensor uses an electroenzymatic approach to determine the amount of glucose and insulin in the blood sample.

The test strip consists of three different electrode layers and immobilized electrochemicals that bind specifically to glucose and insulin, respectively. When blood is placed on the test strip, the analyte (glucose or insulin) binds to their specific aptamer. The transducer converts the analyte-aptamer reaction into an electrical current that is directly proportional to the concentration of the measured biomarker (glucose or insulin). The current is then converted to a voltage, the voltage is amplified and the electronics process the signal. The concentration of glucose and insulin and the calculated insulin resistance is then depicted on the display.

Discover our upcoming handheld device