Insulin resistance is an very important metabolic disorder that affects the large part of the world population. So its early diagnosis have a major role for prevention or avoid of progress. There are several methods to assess insulin resistance like Homeostasis Model Assessment (HOMA), Quantitative Insulin Sensitivity Check Index (QUICKI), Adipose Tissue Insulin Resistance Index (Adipo-IR) and etc. All these models designed with insulin or glucose like metabolites measurements.